Global 5-Hydroxymethylcytosine Levels Are Profoundly Reduced in Multiple Genitourinary Malignancies

Solid tumors are characterized by a plethora of epigenetic changes. In particular, patterns methylation of cytosines at the 5-position (5mC) in the context of CpGs are frequently altered in tumors. Recent evidence suggests that 5mC can get converted to 5-hydroxylmethylcytosine (5hmC) in an enzymatic...

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Veröffentlicht in:PLoS One
Hauptverfasser: Munari, Enrico, Chaux, Alcides, Vaghasia, Ajay M., Taheri, Diana, Karram, Sarah, Bezerra, Stephania M., Gonzalez Roibon, Nilda, Nelson, William G., Yegnasubramanian, Srinivasan, Netto, George J., Haffner, Michael C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718593/
https://ncbi.nlm.nih.gov/pubmed/26785262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0146302
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