Structures of Iridoid Synthase from Cantharanthus roseus with Bound NAD(+), NADPH or NAD(+)/10-Oxogeranial: Reaction Mechanisms

We report the structures of an iridoid synthase, nepetalactol synthase, in the presence of NAD(+), NADPH or NAD(+)/10-oxogeranial. The 10-oxogeranial substrate binds in a transoid-O1-C3 conformation and can be reduced by hydride addition to form S-10-oxo-citronellal, a by-product of the enzyme. Tyr1...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Hu, Yumei, Liu, Weidong, Malwal, Satish R., Zheng, Yingying, Feng, Xinxin, Ko, Tzu-Ping, Chen, Chun-Chi, Xu, Zhongxia, Liu, Meixia, Han, Xu, Gao, Jian, Oldfield, Eric, Guo, Rey-Ting
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718417/
https://ncbi.nlm.nih.gov/pubmed/26768532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201508310
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