PTPRN2 and PLCβ1 promote metastatic breast cancer cell migration through PI(4,5)P(2)‐dependent actin remodeling

Altered abundance of phosphatidyl inositides (PIs) is a feature of cancer. Various PIs mark the identity of diverse membranes in normal and malignant cells. Phosphatidylinositol 4,5‐bisphosphate (PI(4,5)P(2)) resides predominantly in the plasma membrane, where it regulates cellular processes by recr...

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Udgivet i:EMBO J
Main Authors: Sengelaub, Caitlin A, Navrazhina, Kristina, Ross, Jason B, Halberg, Nils, Tavazoie, Sohail F
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2015
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4717998/
https://ncbi.nlm.nih.gov/pubmed/26620550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201591973
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