Synthesis and Evaluation of Oxyguanidine Analogues of the Cysteine Protease Inhibitor WRR-483 against Cruzain

[Image: see text] A series of oxyguanidine analogues of the cysteine protease inhibitor WRR-483 were synthesized and evaluated against cruzain, the major cysteine protease of the protozoan parasite Trypanosoma cruzi. Kinetic analyses of these analogues indicated that they have comparable potency to...

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Bibliografske podrobnosti
izdano v:ACS Med Chem Lett
Main Authors: Jones, Brian D., Tochowicz, Anna, Tang, Yinyan, Cameron, Michael D., McCall, Laura-Isobel, Hirata, Ken, Siqueira-Neto, Jair L., Reed, Sharon L., McKerrow, James H., Roush, William R.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2015
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4716606/
https://ncbi.nlm.nih.gov/pubmed/26819670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00336
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