Role of a Preorganized Scaffold Presenting Four Residues of a GM-3 Lactone Mimetic on Melanoma Progression

[Image: see text] Two tetravalent architectures, the glycocalix 7 and the RAFT 9, presenting four residues of a GM-3 ganglioside lactone mimetic, target the host compartment of melanoma and significantly abrogate the effect induced by cancer-associated fibroblasts (CAFs) contact + hypoxia in the mot...

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: Richichi, Barbara, Comito, Giuseppina, Renaudet, Olivier, Fiore, Michele, Marra, A., Stecca, B., Pasquato, L., Chiarugi, P., Nativi, C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2015
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4716596/
https://ncbi.nlm.nih.gov/pubmed/26819661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00283
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