Pharmacometabolomic Assessments of Atenolol and Hydrochlorothiazide Treatment Reveal Novel Drug Response Phenotypes

Achieving hypertension (HTN) control and mitigating the adverse health effects associated with HTN continues to be a global challenge. Some individuals respond poorly to current HTN therapies, and mechanisms for response variation remain poorly understood. We used a nontargeted metabolomics approach...

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Pubblicato in:CPT Pharmacometrics Syst Pharmacol
Autori principali: Rotroff, DM, Shahin, MH, Gurley, SB, Zhu, H, Motsinger‐Reif, A, Meisner, M, Beitelshees, AL, Fiehn, O, Johnson, JA, Elbadawi‐Sidhu, M, Frye, RF, Gong, Y, Weng, L, Cooper‐DeHoff, RM, Kaddurah‐Daouk, R
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2015
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4716583/
https://ncbi.nlm.nih.gov/pubmed/26783503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12017
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