Suppression of arthritis-induced bone erosion by a CRAC channel antagonist

OBJECTIVE: We have shown in vitro and in vivo that osteoclast maturation requires calcium-release activated calcium (CRAC) channels. In inflammatory arthritis, osteoclasts mediate severe and debilitating bone erosion. In the current study, we assess the value of CRAC channels as a therapeutic target...

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Detalhes bibliográficos
Publicado no:RMD Open
Main Authors: Blair, Harry C, Soboloff, Jonathan, Robinson, Lisa J, Tourkova, Irina L, Larrouture, Quitterie C, Witt, Michelle R, Holaskova, Ida, Schafer, Rosana, Elliott, Meenal, Hirsch, Raphael, Barnett, John B
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2016
Assuntos:
Animal Models
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4716559/
https://ncbi.nlm.nih.gov/pubmed/26819750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/rmdopen-2015-000093
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