BCR-signaling-induced cell death demonstrates dependency on multiple BH3-only proteins in a murine model of B-cell lymphoma

Genetic recombination during B-cell development regularly results in the generation of autoreactive, potentially pathogenic B-cell receptors (BCRs). Consequently, multiple mechanisms link inappropriate BCR specificity to clonal deletion. Similar pathways remain in malignant B cells, offering the pot...

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Détails bibliographiques
Publié dans:Cell Death Differ
Auteurs principaux: Carter, M J, Cox, K L, Blakemore, S J, Bogdanov, Y D, Happo, L, Scott, C L, Strasser, A, Packham, G K, Cragg, M S
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
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Original Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4716310/
https://ncbi.nlm.nih.gov/pubmed/26184912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.97
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