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Exploration of the labeling of [(11)C]Tubastatin A at the hydroxamic acid site with [(11)C]carbon monoxide
We aimed to label tubastatin A (1) with carbon-11 (t(1/2) = 20.4 min) in the hydroxamic acid site to provide a potential radiotracer for imaging histone deacetylase 6 (HDAC6) in vivo with positron emission tomography (PET). Initial attempts at a one-pot Pd-mediated insertion of [(11)C]carbon monoxid...
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| Publicado no: | J Labelled Comp Radiopharm |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4715750/ https://ncbi.nlm.nih.gov/pubmed/26647018 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jlcr.3360 |
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