A potent betulinic acid analogue ascertains an antagonistic mechanism between autophagy and proteasomal degradation pathway in HT-29 cells

BACKGROUND: Betulinic acid (BA), a member of pentacyclic triterpenes has shown important biological activities like anti-bacterial, anti-malarial, anti-inflammatory and most interestingly anticancer property. To overcome its poor aqueous solubility and low bioavailability, structural modifications o...

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Pubblicato in:BMC Cancer
Autori principali: Dutta, Debasmita, Chakraborty, Biswajit, Sarkar, Ankita, Chowdhury, Chinmay, Das, Padma
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4715307/
https://ncbi.nlm.nih.gov/pubmed/26772983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2055-1
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