Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos

Type I neurofibromatosis (NF1) is caused by mutations in the NF1 gene encoding neurofibromin. Neurofibromin exhibits Ras GTPase activating protein (Ras-GAP) activity that is thought to mediate cellular functions relevant to disease phenotypes. Loss of murine Nf1 results in embryonic lethality due to...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Yzaguirre, Amanda D, Padmanabhan, Arun, de Groh, Eric D, Engleka, Kurt A, Li, Jun, Speck, Nancy A, Epstein, Jonathan A
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2015
Pynciau:
Cell Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4714971/
https://ncbi.nlm.nih.gov/pubmed/26460546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.07780
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