Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos

Type I neurofibromatosis (NF1) is caused by mutations in the NF1 gene encoding neurofibromin. Neurofibromin exhibits Ras GTPase activating protein (Ras-GAP) activity that is thought to mediate cellular functions relevant to disease phenotypes. Loss of murine Nf1 results in embryonic lethality due to...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Yzaguirre, Amanda D, Padmanabhan, Arun, de Groh, Eric D, Engleka, Kurt A, Li, Jun, Speck, Nancy A, Epstein, Jonathan A
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2015
Assuntos:
Cell Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4714971/
https://ncbi.nlm.nih.gov/pubmed/26460546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.07780
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