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Deconvolution method for specific and nonspecific binding of ligand to multi-protein complex by native mass spectrometry
In native mass spectrometry, it has been difficult to discriminate between specific binding of a ligand to a multi-protein complex from the nonspecific interactions. Here, we present a deconvolution model that consists of two levels of data reduction. At the first level, the apparent association bin...
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| Publicado no: | Anal Chem |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4714924/ https://ncbi.nlm.nih.gov/pubmed/26189511 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.5b02258 |
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