Folate Deficiency Triggered Apoptosis of Synoviocytes: Role of Overproduction of Reactive Oxygen Species Generated via NADPH Oxidase/Mitochondrial Complex II and Calcium Perturbation

Despite a plethora of literature has documented that osteoarthritis (OA) is veritably associated with oxidative stress-mediated chondrocyte death and matrix degradation, yet the possible involvement of synoviocyte abnormality as causative factor of OA has not been thoroughly investigated. For this r...

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Veröffentlicht in:PLoS One
Hauptverfasser: Hsu, Hung-Chih, Chang, Wen-Ming, Wu, Jin-Yi, Huang, Chin-Chin, Lu, Fung-Jou, Chuang, Yi-Wen, Chang, Pey-Jium, Chen, Kai-Hua, Hong, Chang-Zern, Yeh, Rang-Hui, Liu, Tsan-Zon, Chen, Ching-Hsein
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4714898/
https://ncbi.nlm.nih.gov/pubmed/26771387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0146440
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