Folate Deficiency Triggers an Oxidative-Nitrosative Stress-Mediated Apoptotic Cell Death and Impedes Insulin Biosynthesis in RINm5F Pancreatic Islet β–Cells: Relevant to the Pathogenesis of Diabetes

It has been postulated that folic acid (folate) deficiency (FD) may be a risk factor for the pathogenesis of a variety of oxidative stress-triggered chronic degenerative diseases including diabetes, however, the direct evidence to lend support to this hypothesis is scanty. For this reason, we set ou...

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Hauptverfasser: Hsu, Hung-Chih, Chiou, Jeng-Fong, Wang, Yu-Huei, Chen, Chia-Hui, Mau, Shin-Yi, Ho, Chun-Te, Chang, Pey-Jium, Liu, Tsan-Zon, Chen, Ching-Hsein
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3817167/
https://ncbi.nlm.nih.gov/pubmed/24223745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0077931
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