Histone H3.5 forms an unstable nucleosome and accumulates around transcription start sites in human testis

BACKGROUND: Human histone H3.5 is a non-allelic H3 variant evolutionally derived from H3.3. The H3.5 mRNA is highly expressed in human testis. However, the function of H3.5 has remained poorly understood. RESULTS: We found that the H3.5 nucleosome is less stable than the H3.3 nucleosome. The crystal...

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Veröffentlicht in:Epigenetics Chromatin
Hauptverfasser: Urahama, Takashi, Harada, Akihito, Maehara, Kazumitsu, Horikoshi, Naoki, Sato, Koichi, Sato, Yuko, Shiraishi, Koji, Sugino, Norihiro, Osakabe, Akihisa, Tachiwana, Hiroaki, Kagawa, Wataru, Kimura, Hiroshi, Ohkawa, Yasuyuki, Kurumizaka, Hitoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4714512/
https://ncbi.nlm.nih.gov/pubmed/26779285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-016-0051-y
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