Oxysterol-binding Protein Activation at Endoplasmic Reticulum-Golgi Contact Sites Reorganizes Phosphatidylinositol 4-Phosphate Pools

Oxysterol-binding protein (OSBP) exchanges cholesterol and phosphatidylinositol 4-phosphate (PI-4P) at contact sites between the endoplasmic reticulum (ER) and the trans-Golgi/trans-Golgi network. 25-Hydroxycholesterol (25OH) competitively inhibits this exchange reaction in vitro and causes the cons...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Goto, Asako, Charman, Mark, Ridgway, Neale D.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Lipids
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4714219/
https://ncbi.nlm.nih.gov/pubmed/26601944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.682997
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