Insulin Dissociates the Effects of Liver X Receptor on Lipogenesis, Endoplasmic Reticulum Stress, and Inflammation

Diabetes is characterized by increased lipogenesis as well as increased endoplasmic reticulum (ER) stress and inflammation. The nuclear hormone receptor liver X receptor (LXR) is induced by insulin and is a key regulator of lipid metabolism. It promotes lipogenesis and cholesterol efflux, but suppre...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Sun, Xiaowei, Haas, Mary E., Miao, Ji, Mehta, Abhiruchi, Graham, Mark J., Crooke, Rosanne M., de Barros, Jean-Paul Pais, Wang, Jian-Guo, Aikawa, Masanori, Masson, David, Biddinger, Sudha B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Lipids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4714195/
https://ncbi.nlm.nih.gov/pubmed/26511317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.668269
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