In Vivo Differences between Two Optical Isomers of Radioiodinated o-iodo-trans-decalinvesamicol for Use as a Radioligand for the Vesicular Acetylcholine Transporter

PURPOSE: To develop a superior VAChT imaging probe for SPECT, radiolabeled (-)-OIDV and (+)-OIDV were isolated and investigated for differences in their binding affinity and selectivity to VAChT, as well as their in vivo activities. PROCEDURES: Radioiodinated o-iodo-trans-decalinvesamicol ([(125)I]O...

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Publicat a:PLoS One
Autors principals: Uno, Izumi, Kozaka, Takashi, Miwa, Daisuke, Kitamura, Yoji, Azim, Mohammad Anwar-ul, Ogawa, Kazuma, Taki, Junichi, Kinuya, Seigo, Shiba, Kazuhiro
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4713475/
https://ncbi.nlm.nih.gov/pubmed/26752172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0146719
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