LANOSTEROL SYNTHASE GENE POLYMORPHISMS AND CHANGES IN ENDOGENOUS OUABAIN IN THE RESPONSE TO LOW SODIUM INTAKE

Circulating levels of endogenous ouabain (EO), a vasopressor hormone of adrenocortical origin, are increased by sodium depletion. Further, lanosterol synthase (LSS), an enzyme involved in cholesterol biosynthesis, has a missense polymorphism (rs2254524 V642L) that affects EO biosynthesis in adrenoco...

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Publié dans:Hypertension
Auteurs principaux: LANZANI, Chiara, GATTI, Guido, CITTERIO, Lorena, MESSAGGIO, Elisabetta, DELLI CARPINI, Simona, SIMONINI, Marco, CASAMASSIMA, Nunzia, ZAGATO, Laura, BRIONI, Elena, HAMLYN, John M., MANUNTA, Paolo
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4713326/
https://ncbi.nlm.nih.gov/pubmed/26667413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.115.06415
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