Relationships among endogenous ouabain, α-adducin polymorphisms and renal sodium handling in primary hypertension

OBJECTIVE: The basolateral Na pump drives renotubular reabsorption. In cultured renal cells, mutant adducins, as well as sub-nanomolar ouabain concentrations, stimulate the Na–K pump. METHODS: To determine whether these factors interact and affect Na handling and blood pressure (BP) in vivo, we stud...

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Autores principales: Manunta, Paolo, Maillard, Marc, Tantardini, Cristina, Simonini, Marco, Lanzani, Chiara, Citterio, Lorena, Stella, Paola, Casamassima, Nunzia, Burnier, Michel, Hamlyn, John M., Bianchi, Giuseppe
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518487/
https://ncbi.nlm.nih.gov/pubmed/18398333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/HJH.0b013e3282f5315f
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