TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-pneumococcal Immunity

Monocyte phenotype and output changes with age, but why this occurs and how it impacts anti-bacterial immunity are not clear. We found that, in both humans and mice, circulating monocyte phenotype and function was altered with age due to increasing levels of TNF in the circulation that occur as part...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS Pathog
Prif Awduron: Puchta, Alicja, Naidoo, Avee, Verschoor, Chris P., Loukov, Dessi, Thevaranjan, Netusha, Mandur, Talveer S., Nguyen, Phuong-son, Jordana, Manel, Loeb, Mark, Xing, Zhou, Kobzik, Lester, Larché, Maggie J., Bowdish, Dawn M. E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2016
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4713203/
https://ncbi.nlm.nih.gov/pubmed/26766566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005368
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