TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-pneumococcal Immunity

Monocyte phenotype and output changes with age, but why this occurs and how it impacts anti-bacterial immunity are not clear. We found that, in both humans and mice, circulating monocyte phenotype and function was altered with age due to increasing levels of TNF in the circulation that occur as part...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:PLoS Pathog
المؤلفون الرئيسيون: Puchta, Alicja, Naidoo, Avee, Verschoor, Chris P., Loukov, Dessi, Thevaranjan, Netusha, Mandur, Talveer S., Nguyen, Phuong-son, Jordana, Manel, Loeb, Mark, Xing, Zhou, Kobzik, Lester, Larché, Maggie J., Bowdish, Dawn M. E.
التنسيق: Artigo
اللغة:Inglês
منشور في: Public Library of Science 2016
الموضوعات:
Research Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC4713203/
https://ncbi.nlm.nih.gov/pubmed/26766566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005368
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