TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-pneumococcal Immunity

Monocyte phenotype and output changes with age, but why this occurs and how it impacts anti-bacterial immunity are not clear. We found that, in both humans and mice, circulating monocyte phenotype and function was altered with age due to increasing levels of TNF in the circulation that occur as part...

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Pubblicato in:PLoS Pathog
Autori principali: Puchta, Alicja, Naidoo, Avee, Verschoor, Chris P., Loukov, Dessi, Thevaranjan, Netusha, Mandur, Talveer S., Nguyen, Phuong-son, Jordana, Manel, Loeb, Mark, Xing, Zhou, Kobzik, Lester, Larché, Maggie J., Bowdish, Dawn M. E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4713203/
https://ncbi.nlm.nih.gov/pubmed/26766566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005368
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