Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells

Memory CD8(+) T cells are critical for host defense upon reexposure to intracellular pathogens. We found that interleukin 10 (IL-10) derived from CD4(+) regulatory T cells (T(reg) cells) was necessary for the maturation of memory CD8(+) T cells following acute infection with lymphocytic choriomening...

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Pubblicato in:Nat Immunol
Autori principali: Laidlaw, Brian J, Cui, Weiguo, Amezquita, Robert A, Gray, Simon M, Guan, Tianxia, Lu, Yisi, Kobayashi, Yasushi, Flavell, Richard A, Kleinstein, Steven H, Craft, Joe, Kaech, Susan M
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4713030/
https://ncbi.nlm.nih.gov/pubmed/26147684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3224
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