PIWI Slicing and EXD1 Drive Biogenesis of Nuclear piRNAs from Cytosolic Targets of the Mouse piRNA Pathway

PIWI-interacting RNAs (piRNAs) guide PIWI proteins to suppress transposons in the cytoplasm and nucleus of animal germ cells, but how silencing in the two compartments is coordinated is not known. Here we demonstrate that endonucleolytic slicing of a transcript by the cytosolic mouse PIWI protein MI...

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Veröffentlicht in:Mol Cell
Hauptverfasser: Yang, Zhaolin, Chen, Kuan-Ming, Pandey, Radha Raman, Homolka, David, Reuter, Michael, Janeiro, Bruno Kotska Rodino, Sachidanandam, Ravi, Fauvarque, Marie-Odile, McCarthy, Andrew A., Pillai, Ramesh S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4712191/
https://ncbi.nlm.nih.gov/pubmed/26669262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.11.009
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