Inhibition of Contractile Function in Human Joint Capsule Myofibroblasts by Targeting the TGF-β1 and PDGF Pathways

BACKGROUND: Contractile myofibroblasts (MFs) accumulate in the joint capsules of patients suffering from posttraumatic joint stiffness. MF activation is controlled by a complex local network of growth factors and cytokines, ending in the increased production of extracellular matrix components follow...

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Udgivet i:PLoS One
Main Authors: Mattyasovszky, Stefan G., Wollstädter, Jochen, Martin, Anne, Ritz, Ulrike, Baranowski, Andreas, Ossendorf, Christian, Rommens, Pol M., Hofmann, Alexander
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4712129/
https://ncbi.nlm.nih.gov/pubmed/26730954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145948
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