Inhibition of Contractile Function in Human Joint Capsule Myofibroblasts by Targeting the TGF-β1 and PDGF Pathways.

Contractile myofibroblasts (MFs) accumulate in the joint capsules of patients suffering from posttraumatic joint stiffness. MF activation is controlled by a complex local network of growth factors and cytokines, ending in the increased production of extracellular matrix components followed by soft t...

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Autores principales: Stefan G Mattyasovszky, Jochen Wollstädter, Anne Martin, Ulrike Ritz, Andreas Baranowski, Christian Ossendorf, Pol M Rommens, Alexander Hofmann
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science (PLoS) 2016-01-01
Colección:PLoS ONE
Acceso en línea:http://europepmc.org/articles/PMC4712129?pdf=render
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http://europepmc.org/articles/PMC4712129?pdf=render