Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug

Therapeutic nanoparticles (TNPs) aim to deliver drugs more safely and effectively to cancers, yet clinical results have been unpredictable owing to limited in vivo understanding. Here we use single-cell imaging of intratumoral TNP pharmacokinetics and pharmacodynamics to better comprehend their hete...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Miller, Miles A., Zheng, Yao-Rong, Gadde, Suresh, Pfirschke, Christina, Zope, Harshal, Engblom, Camilla, Kohler, Rainer H., Iwamoto, Yoshiko, Yang, Katherine S., Askevold, Bjorn, Kolishetti, Nagesh, Pittet, Mikael, Lippard, Stephen J., Farokhzad, Omid C., Weissleder, Ralph
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4711745/
https://ncbi.nlm.nih.gov/pubmed/26503691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9692
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