Interferon alpha (IFNα)-induced TRIM22 interrupts HCV replication by ubiquitinating NS5A

TRIM22, a tripartite-motif (TRIM) protein, is upregulated upon interferon alpha (IFNα) administration to hepatitis C virus (HCV)-infected patients. However, the physiological role of TRIM22 upregulation remains unclear. Here, we describe a potential antiviral function of TRIM22's targeting of t...

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Publicat a:Cell Mol Immunol
Autors principals: Yang, Chen, Zhao, Xinhao, Sun, Dakang, Yang, Leilei, Chong, Chang, Pan, Yu, Chi, Xiumei, Gao, Yanhang, Wang, Moli, Shi, Xiaodong, Sun, Haibo, Lv, Juan, Gao, Yuanda, Zhong, Jin, Niu, Junqi, Sun, Bing
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4711679/
https://ncbi.nlm.nih.gov/pubmed/25683609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2014.131
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