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Trifluoroacetic acid as excipient destabilizes melittin causing the selective aggregation of melittin within the centrin-melittin-trifluoroacetic acid complexa)

Trifluoroacetic acid (TFA) may be the cause of the bottleneck in high resolution structure determination for protein-peptide complexes. Fragment based drug design often involves the use of synthetic peptides which contain TFA (excipient). Our goal was to explore the effects of this excipient on a mo...

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Detalhes bibliográficos
Publicado no:Struct Dyn
Main Authors: Pastrana-Rios, Belinda, del Valle Sosa, Liliana, Santiago, Jorge
Formato: Artigo
Idioma:Inglês
Publicado em: American Crystallographic Association 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4711628/
https://ncbi.nlm.nih.gov/pubmed/26798810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1063/1.4921219
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