Tmc1 Point Mutation Affects Ca(2+) Sensitivity and Block by Dihydrostreptomycin of the Mechanoelectrical Transducer Current of Mouse Outer Hair Cells

The transduction of sound into electrical signals depends on mechanically sensitive ion channels in the stereociliary bundle. The molecular composition of this mechanoelectrical transducer (MET) channel is not yet known. Transmembrane channel-like protein isoforms 1 (TMC1) and 2 (TMC2) have been pro...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Corns, Laura F., Johnson, Stuart L., Kros, Corné J., Marcotti, Walter
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4710764/
https://ncbi.nlm.nih.gov/pubmed/26758827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2439-15.2016
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