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LH-Induced Steroidogenesis in the Mouse Ovary, but Not Testis, Requires Matrix Metalloproteinase 2- and 9-Mediated Cleavage of Upregulated EGF Receptor Ligands

Oocyte maturation and cumulus cell expansion depend on luteinizing hormone (LH)-mediated upregulation of membrane-bound epidermal growth factor (EGF)-like ligands, including amphiregulin, epiregulin, and betacellulin. These ligands then transactivate the EGF receptor (EGFR) after release by matrix m...

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Dades bibliogràfiques
Publicat a:Biol Reprod
Autors principals: Light, Allison, Hammes, Stephen R.
Format: Artigo
Idioma:Inglês
Publicat: Society for the Study of Reproduction, Inc. 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4710187/
https://ncbi.nlm.nih.gov/pubmed/26203177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1095/biolreprod.115.130971
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