Uniform brain tumor distribution and tumor associated macrophage targeting of systemically administered dendrimers

Effective blood–brain tumor barrier penetration and uniform solid tumor distribution can significantly enhance therapeutic delivery to brain tumors. Hydroxyl-functionalized, generation-4 poly(amidoamine) (PAMAM) dendrimers, with their small size, near-neutral surface charge, and the ability to selec...

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Publicado en:Biomaterials
Autores principales: Zhang, Fan, Mastorakos, Panagiotis, Mishra, Manoj K., Mangraviti, Antonella, Hwang, Lee, Zhou, Jinyuan, Hanes, Justin, Brem, Henry, Olivi, Alessandro, Tyler, Betty, Kannan, Rangaramanujam M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4710089/
https://ncbi.nlm.nih.gov/pubmed/25818456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2015.02.053
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