Uniform brain tumor distribution and tumor associated macrophage targeting of systemically administered dendrimers

Effective blood–brain tumor barrier penetration and uniform solid tumor distribution can significantly enhance therapeutic delivery to brain tumors. Hydroxyl-functionalized, generation-4 poly(amidoamine) (PAMAM) dendrimers, with their small size, near-neutral surface charge, and the ability to selec...

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Detalhes bibliográficos
Publicado no:Biomaterials
Main Authors: Zhang, Fan, Mastorakos, Panagiotis, Mishra, Manoj K., Mangraviti, Antonella, Hwang, Lee, Zhou, Jinyuan, Hanes, Justin, Brem, Henry, Olivi, Alessandro, Tyler, Betty, Kannan, Rangaramanujam M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4710089/
https://ncbi.nlm.nih.gov/pubmed/25818456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2015.02.053
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