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The discriminator base influences tRNA structure at the end of the acceptor stem and possibly its interaction with proteins.

For many tRNAs, the discriminator base preceding the CCA sequence at the 3' end is important for aminoacylation. We show that the discriminator base influences the stability of the 1.72 base pair onto which it is stacked. Mutations of the discriminator base from adenosine to cytidine or uridine make...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Lee, C P, Mandal, N, Dyson, M R, RajBhandary, U L
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47093/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8346229/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.15.7149
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