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Structural studies on tRNA acceptor stem microhelices: exchange of the discriminator base A73 for G in human tRNALeu switches the acceptor specificity from leucine to serine possibly by decreasing the stability of the terminal G1-C72 base pair.

Correct recognition of transfer RNAs (tRNAs) by aminoacyl-tRNA synthetases (aaRS) is crucial to the maintenance of translational fidelity. The discriminator base A73 in human tRNALeuis critical for its specific recognition by the aaRS. Exchanging A73 for G abolishes leucine acceptance and converts i...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Metzger, A U, Heckl, M, Willbold, D, Breitschopf, K, RajBhandary, U L, Rösch, P, Gross, H J
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 1997
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC147070/
https://ncbi.nlm.nih.gov/pubmed/9358165
Tagiau: Ychwanegu Tag
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