Structural studies on tRNA acceptor stem microhelices: exchange of the discriminator base A73 for G in human tRNALeu switches the acceptor specificity from leucine to serine possibly by decreasing the stability of the terminal G1-C72 base pair.

Correct recognition of transfer RNAs (tRNAs) by aminoacyl-tRNA synthetases (aaRS) is crucial to the maintenance of translational fidelity. The discriminator base A73 in human tRNALeuis critical for its specific recognition by the aaRS. Exchanging A73 for G abolishes leucine acceptance and converts i...

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Publicado en:	Nucleic Acids Res
Autores principales:	Metzger, A U, Heckl, M, Willbold, D, Breitschopf, K, RajBhandary, U L, Rösch, P, Gross, H J
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Oxford University Press 1997
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147070/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9358165/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.22.4551
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