A Spectroscopic Approach to Investigate the Molecular Interactions between the Newly Approved Irreversible ErbB blocker "Afatinib" and Bovine Serum Albumin

The interaction of afatinib (AFB) with bovine serum albumin (BSA) was examined via fluorescence and UV-Vis spectroscopy. Spectrofluorimetric measurements revealed that AFB can strongly quench the BSA intrinsic fluorescence through producing a non-fluorescent complex. This quenching mechanism was tho...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Alanazi, Amer M., Abdelhameed, Ali Saber
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2016
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4709191/
https://ncbi.nlm.nih.gov/pubmed/26751077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0146297
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