Efficacy of afatinib, an irreversible ErbB family blocker, in the treatment of intracerebral metastases of non-small cell lung cancer in mice

Few effective therapeutic options are currently available for the treatment of non-small cell lung cancer (NSCLC) with brain metastases (BM). Recent evidence shows that NSCLC patients with BMs respond well to afatinib, but little is known about the underlying mechanisms. In this study, we evaluated...

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Detalhes bibliográficos
Publicado no:Acta Pharmacol Sin
Main Authors: Zhang, Shi-rong, Zhu, Lu-cheng, Jiang, Yan-ping, Zhang, Jing, Xu, Ru-jun, Xu, Ya-si, Xia, Bing, Ma, Sheng-lin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309749/
https://ncbi.nlm.nih.gov/pubmed/27840411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2016.107
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