Efficacy of afatinib, an irreversible ErbB family blocker, in the treatment of intracerebral metastases of non-small cell lung cancer in mice

Few effective therapeutic options are currently available for the treatment of non-small cell lung cancer (NSCLC) with brain metastases (BM). Recent evidence shows that NSCLC patients with BMs respond well to afatinib, but little is known about the underlying mechanisms. In this study, we evaluated...

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Veröffentlicht in:Acta Pharmacol Sin
Hauptverfasser: Zhang, Shi-rong, Zhu, Lu-cheng, Jiang, Yan-ping, Zhang, Jing, Xu, Ru-jun, Xu, Ya-si, Xia, Bing, Ma, Sheng-lin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309749/
https://ncbi.nlm.nih.gov/pubmed/27840411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2016.107
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