Gene delivery of antioxidant enzymes inhibits HIV-1 gp120-induced expression of caspases

Caspases are implicated in neuronal death in neurodegenerative and other Central Nervous System (CNS) diseases. In a rat model of HIV-1 associated neurocognitive disorders (HAND), we previously characterized HIV-1 envelope gp120-induced neuronal apoptosis by TUNEL assay. In this model, neuronal apop...

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Udgivet i:Neuroscience
Main Authors: Louboutin, Jean-Pierre, Agrawal, Lokesh, Reyes, Beverly A.S., Van Bockstaele, Elisabeth J, Strayer, David S
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4707961/
https://ncbi.nlm.nih.gov/pubmed/22531373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2012.03.061
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