The E3 ubiquitin ligase TRIM9 is a filopodia off switch required for netrin dependent axon guidance

Neuronal growth cone filopodia contain guidance receptors and contribute to axon guidance, however the mechanism by which the guidance cue netrin increases filopodia density is unknown. Here we demonstrate that TRIM9, an E3 ubiquitin ligase that localizes to filopodia tips and binds the netrin recep...

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Detalhes bibliográficos
Publicado no:Dev Cell
Main Authors: Menon, Shalini, Boyer, Nicholas Patrick, Winkle, Cortney Chelise, McClain, Leslie Marie, Hanlin, Christopher Carey, Pandey, Dharmendra, Rothenfußer, Simon, Taylor, Anne Marion, Gupton, Stephanie Lynn
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4707677/
https://ncbi.nlm.nih.gov/pubmed/26702829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2015.11.022
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