Glutathione Depletion Accelerates Cigarette Smoke-Induced Inflammation and Airspace Enlargement

The study objective was to assess age-related changes in glutathione (GSH) adaptive response to cigarette smoke (CS) exposure. Older cigarette smokers show a decline (67%) in lung epithelial lining fluid (ELF) GSH and a 1.8-fold decreased GSH adaptive response to cigarette smoking with a concomitant...

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Détails bibliographiques
Publié dans:Toxicol Sci
Auteurs principaux: Gould, Neal S., Min, Elysia, Huang, Jie, Chu, Hong Wei, Good, Jim, Martin, Richard J., Day, Brian J.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2015
Sujets:
Role of Glutathione in Mediating Cigarette Smoke-Induced Airway Damage
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4707200/
https://ncbi.nlm.nih.gov/pubmed/26149495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv143
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