Dual agonist Surrobody™ simultaneously activates death receptors DR4 and DR5 to induce cancer cell death

Death receptors of the Tumor Necrosis Factor (TNF) family are found on surface of most cancer cells and their activation typically kills cancer cells through the stimulation of the extrinsic apoptotic pathway. The endogenous ligand for death receptors-4 and -5 (DR4 and DR5) is Tumor Necrosis Factor-...

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Pubblicato in:Mol Cancer Ther
Autori principali: Milutinovic, Snezana, Kashyap, Arun K., Yanagi, Teruki, Wimer, Carina, Zhou, Sihong, O' Neil, Ryann, Kurtzman, Aaron L., Faynboym, Alexsandr, Xu, Li, Hannum, Charles H., Diaz, Paul W., Matsuzawa, Shu-ichi, Horowitz, Michael, Horowitz, Lawrence, Bhatt, Ramesh R., Reed, John C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4707094/
https://ncbi.nlm.nih.gov/pubmed/26516157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0400
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