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Interleukin 12-dependent Cytomegalovirus-Specific CD4(+) T cell Proliferation, T-bet induction and Effector Multi-function during Primary Infection are Key Determinants for Early Immune Control

CMV remains an important opportunistic pathogen in solid organ and hematopoietic cell transplantation, particularly in lung transplant recipients (LTRs). LTRs mismatched for CMV (donor+/recipient−; D+R−) are at high-risk for active CMV infection and increased mortality; however the immune correlates...

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Podrobná bibliografie
Vydáno v:J Immunol
Hlavní autoři: Popescu, Iulia, Pipeling, Matthew R., Mannem, Hannah, Shah, Pali D., Orens, Jonathan B., Connors, Mark, Migueles, Stephen A., McDyer, John F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4707074/
https://ncbi.nlm.nih.gov/pubmed/26663780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1501589
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