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Interleukin 12-dependent Cytomegalovirus-Specific CD4(+) T cell Proliferation, T-bet induction and Effector Multi-function during Primary Infection are Key Determinants for Early Immune Control

CMV remains an important opportunistic pathogen in solid organ and hematopoietic cell transplantation, particularly in lung transplant recipients (LTRs). LTRs mismatched for CMV (donor+/recipient−; D+R−) are at high-risk for active CMV infection and increased mortality; however the immune correlates...

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書誌詳細
出版年:J Immunol
主要な著者: Popescu, Iulia, Pipeling, Matthew R., Mannem, Hannah, Shah, Pali D., Orens, Jonathan B., Connors, Mark, Migueles, Stephen A., McDyer, John F.
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4707074/
https://ncbi.nlm.nih.gov/pubmed/26663780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1501589
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