Intact Purine Biosynthesis Pathways Are Required for Wild-Type Virulence of Brucella abortus 2308 in the BALB/c Mouse Model

Brucella abortus 2308 derivatives with mini-Tn5 insertions in purE, purL, and purD display significant attenuation in the BALB/c mouse model, while isogenic mutants with mini-Tn5 insertions in pheA, trpB, and dagA display little or no attenuation in cultured murine macrophages or mice. These experim...

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Hauptverfasser: Alcantara, Rosemarie B., Read, Richard D. A., Valderas, Michelle Wright, Brown, Timothy D., Roop, R. Martin
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2004
Schlagworte:
Bacterial Infections
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC470684/
https://ncbi.nlm.nih.gov/pubmed/15271960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.8.4911-4917.2004
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