Intact Purine Biosynthesis Pathways Are Required for Wild-Type Virulence of Brucella abortus 2308 in the BALB/c Mouse Model

Brucella abortus 2308 derivatives with mini-Tn5 insertions in purE, purL, and purD display significant attenuation in the BALB/c mouse model, while isogenic mutants with mini-Tn5 insertions in pheA, trpB, and dagA display little or no attenuation in cultured murine macrophages or mice. These experim...

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Udgivet i:Infect Immun
Main Authors: Alcantara, Rosemarie B., Read, Richard D. A., Valderas, Michelle Wright, Brown, Timothy D., Roop, R. Martin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2004
Fag:
Bacterial Infections
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC470684/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15271960/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.72.8.4911-4917.2004
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