Cargando...

“Monoallelic germline methylation and sequence variant in the promoter of the RB1 gene: a possible constitutive epimutation in hereditary retinoblastoma”

BACKGROUND: Retinoblastoma is a malignant tumor of the retina in children <5 years of age and occurs after two mutations in the RB1 gene. The first mutation (M1) is germinal and confers predisposition to the hereditary type, which is transmitted as an autosomal dominant highly penetrant trait, so...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Clin Epigenetics
Autores principales: Quiñonez-Silva, Guadalupe, Dávalos-Salas, Mercedes, Recillas-Targa, Félix, Ostrosky-Wegman, Patricia, Aranda, Diego Arenas, Benítez-Bribiesca, Luis
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4706693/
https://ncbi.nlm.nih.gov/pubmed/26753011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-015-0167-0
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!