Both HDAC5 and HDAC6 are required for the proliferation and metastasis of melanoma cells

BACKGROUND: Histone deacetylase (HDAC) inhibitors are widely used in clinical investigation as novel drug targets. For example, panobinostat and vorinostat have been used to treat patients with melanoma. However, HDAC inhibitors are small-molecule compounds without a specific target, and their mecha...

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Vydáno v:J Transl Med
Hlavní autoři: Liu, Jiaqi, Gu, Jianying, Feng, Zihao, Yang, Yanhong, Zhu, Ningwen, Lu, Weiyue, Qi, Fazhi
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4706654/
https://ncbi.nlm.nih.gov/pubmed/26747087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-015-0753-0
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