Both HDAC5 and HDAC6 are required for the proliferation and metastasis of melanoma cells

BACKGROUND: Histone deacetylase (HDAC) inhibitors are widely used in clinical investigation as novel drug targets. For example, panobinostat and vorinostat have been used to treat patients with melanoma. However, HDAC inhibitors are small-molecule compounds without a specific target, and their mecha...

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Publicado en:J Transl Med
Autores principales: Liu, Jiaqi, Gu, Jianying, Feng, Zihao, Yang, Yanhong, Zhu, Ningwen, Lu, Weiyue, Qi, Fazhi
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4706654/
https://ncbi.nlm.nih.gov/pubmed/26747087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-015-0753-0
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