Both HDAC5 and HDAC6 are required for the proliferation and metastasis of melanoma cells

BACKGROUND: Histone deacetylase (HDAC) inhibitors are widely used in clinical investigation as novel drug targets. For example, panobinostat and vorinostat have been used to treat patients with melanoma. However, HDAC inhibitors are small-molecule compounds without a specific target, and their mecha...

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Bibliographic Details
Published in:J Transl Med
Main Authors: Liu, Jiaqi, Gu, Jianying, Feng, Zihao, Yang, Yanhong, Zhu, Ningwen, Lu, Weiyue, Qi, Fazhi
Format: Artigo
Language:Inglês
Published: BioMed Central 2016
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4706654/
https://ncbi.nlm.nih.gov/pubmed/26747087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-015-0753-0
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