N19 Polyepitope as a Carrier for Enhanced Immunogenicity and Protective Efficacy of Meningococcal Conjugate Vaccines

N19, a string of human universal CD4 T-cell epitopes from various pathogen-derived antigens, was shown to exert a stronger carrier effect than CRM197 for the induction of anti-group C Neisseria meningitidis capsular polysaccharide (MenC), after immunization of mice with various dosages of N19-MenC o...

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Main Authors: Baraldo, Karin, Mori, Elena, Bartoloni, Antonella, Petracca, Roberto, Giannozzi, Aldo, Norelli, Francesco, Rappuoli, Rino, Grandi, Guido, Del Giudice, Giuseppe
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2004
Ábhair:
Molecular Pathogenesis
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC470654/
https://ncbi.nlm.nih.gov/pubmed/15271954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.8.4884-4887.2004
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