TLR4 regulates pulmonary vascular homeostasis and remodeling via redox signaling

Pulmonary arterial hypertension (PAH) contributes to morbidity and mortality of patients with lung and heart diseases. We demonstrated that hypoxia induced PAH and increased pulmonary arterial wall thickness in wild-type mice. Mice deficient in toll-like receptor 4 (TLR4−/−) spontaneously developed...

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Published in:Front Biosci (Landmark Ed)
Main Authors: Ma, Liping, Ambalavanan, Namasivayam, Liu, Hui, Sun, Yong, Jhala, Nirag, Bradley, Wayne E., Dell’Italia, Louis J., Michalek, Sue, Wu, Hui, Steele, Chad, Benza, Raymond L, Chen, Yabing
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4706231/
https://ncbi.nlm.nih.gov/pubmed/26709781
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